Bedeutung des ABCTransporters MRP2/cMOAT/ABCC2 bei der Cisplatinresistenz humaner Tumorzellen DISSERTATION zur Erlangung des akademischen Grades doctor rerum naturalium (Dr rer nat) im Fach Biologie eingereicht an der MathematischNaturwissenschaftlichen Fakultät I der HumboldtUniversität zu Berlin von Verena Waltraut Materna, geb SchaubOverexpression of either of the multidrug resistance genes MDR1 and MRP is associated with resistance of tumors to multiple chemotherapeutic agents Overexpression of MDR1 has been reported in some cell lines derived from human hepatocellular carcinomas (HCC) and hepatoblastomas (HB) The human gene for cMOAT ( The exporter ABCC2 (cMOAT, MRP2) is a membranebound protein on the apical side of enterocytes and hepatic biliary vessels that transports leukotriene C4, glutathione, some conjugated bile salts, drugs, xenobiotics, and phytonutrients The latter class includes quercetin, a bioactive flavonoid found in foods such as onions, apples, tea, and wine
Dexamethasone Modulation Of Multidrug Transporters In Normal Tissues Demeule 1999 Febs Letters Wiley Online Library
Cmoat
Cmoat- By screening databases of human expressed sequence tags, we have identified three new homologues of MRP1 , the gene encoding the multidrug resistanceassociated protein, and cMOAT (or MRP2 ), the canalicular multispecific organic anion transporter gene We call these new genes MRP3, MRP4 , and MRP5 MRP3 , like cMOAT , is mainly expressed in the liverFind SigmaAldrichSAB MSDS, related peerreviewed papers, technical documents, similar products &
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Since both Pgp and cMOAT are expressed in the intestine, liver, and kidney, it is likely that these efflux transporters play a significant role limiting the oral absorption and disposition of this important anticancer drug Irinotecan (CPT11) is a watersoluble camptothecin (CPT) derivative that has been recently approved in the United States for patients as a firstline therapyMonoclonal AntiABCC2 antibody produced in mouse clone 2H6, purified immunoglobulin, buffered aqueous solution;Synonym ABC30, CMOAT, DJS, KIAA1010, MRP2, cMRP;
Because genistein and its metabolites are substrates for cmoat, inhibition of anion secretion by genistein is partially explained by competition for this transporter Genistein is also a substrate of uridindiphosphate (UDP)glucuronyltransferase isoenzyme(s) Inhibition of glucuronidation reduces the availability of bilirubin and rhodamine glucuronates for transport via cmoat The enhanced expression of the human ABC transporter, cMOAT (MRP2/ABCC2), is associated with resistance of tumor cells against platinumcontaining compounds, such as cisplatin Therefore, cMOAT3 Comat SMS Relay Bedienungsanleitung SMS Relay V0216 1 Einführung 11 Kurzbeschreibung SMS Relay CMS Comat Message System Das SMS Relay CMS10 von Comat ist ein Fernwirk und MeldesystemSechs als analog
Check CMOAT meaning is Canalicular Multispecific Organic Anion Transporter where all Abbreviation, Acronym of CMOAT is available with complete definition which really helps to understand its Full Form name in different interest and terminologyHet cMOATgen (canalicular multispecific organic anion transporter;For a long time, trade portals could only speculate on questions like these Now BusinessIQ can provide answers Our studies provide deep insights into the business world tangible figures and studies instead of assumptions or hollow
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What are the world's most important business topics?The multidrug resistance protein 2 (Mrp2) also called canalicular multidrug resistance protein (cMrp) or canalicular multispecific organic anion transporter (cMoat) is a transmembrane export pump located at the canalicular domain of hepatocytes Mrp2 transports a broad spectrum of organic anions including glucuronides, glutathione conjugates, and organic sulphates into bile Pathology CMOAT abbreviation meaning defined here What does CMOAT stand for in Pathology?
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Molecular Aspects Of Organic Compound Transport Across The Plasma Membrane Of Hepatocytes Kamisako 1999 Journal Of Gastroenterology And Hepatology Wiley Online Library
A cDNA for rat cMOAT, a protein homologous to the multidrug resistance proteins located in the canalicular membrane of hepatocytes, has recently been characterized 85 Molecular biological methods in diagnosis and treatment of liver diseases More results Hierbei konnte neben der verstärkten Expression von ABCTransportern, wie PGlykoprotein (PGp), "Breast Cancer Resistance Protein" (BCRP) sowie "canalicular Multispecific Organic Anion Transporter" (cMOAT), eine intrazelluläre Kompartimentierung von Zytostatika, Modulation der Aktivität von DNATopoisomerasen II (Topo II) sowie Veränderungen in derJahrgang (Volume) 12 Seiten (Pages)
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Enhanced Transport Of Anticancer Agents And Leukotriene C4 By The Human Canalicular Multispecific Organic Anion Transporter Cmoat Mrp2 Kawabe 1999 Febs Letters Wiley Online Library
What are decision makers really interested in?Advanced neuroblastoma and malignant liver tumor are representative childhood cancers for which combined chemotherapy including cisplatin and doxorubicin is Evers et al (1998), who referred to cMOAT as multidrug resistanceassociated protein2 (MRP2), studied its drug export activity in polarized kidney in MDCK cellsIn contrast to MRP1 (), cMOAT was found predominantly intracellularly in nonpolarized cells, suggesting the cMOAT requires a polarized cell for plasma membrane routingThey found that when kidney
Multidrug Resistance Protein
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Die MRP2 bis 5 werden auch als multispezifische Organische AnionTransporter bezeichnet (cMOAT, MOATD, MOATB, MOATC) Molekularepidemiologische Betrachtungen Der menschliche Körper verfügt über ein sehr effektives Schutzsystem, das es ermöglicht, die Bildung eventuell schädigender Noxen zu unterbinden, solche abzufangen oder die entstandenenLooking for the definition of CMOAT?Get the top CMOAT abbreviation related to Pathology
Interaction Of Positional Isomers Of Quercetin Glucuronides With The Transporter Abcc2 Cmoat Mrp2 Drug Metabolism Disposition
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A gene on chromosome 10q24 that encodes a protein of the MRP subfamily of the superfamily of ATPbinding cassette (ABC) transporters, which transport various molecules across extra and intracellular membranes, many of which are involved in multidrug resistanceTitel ABCC2 (MRP2, cMOAT) can be localized in the nuclear membrane of ovarian carcinomas and correlates with resistance to cisplatin and clinical outcome Zeitschrift (Journal) Clin Cancer Res Jahr 06;Characterization of MOATC and MOATD, new members of the MRP/cMOAT subfamily of transporter proteins Belinsky MG, Bain LJ, Balsara BB, Testa JR, Kruh GD BACKGROUNDMultidrug resistanceassociated protein (MRP) and canalicular multispecific organic anion transporter (cMOAT) are transporter proteins that pump organic anions across cellular
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Cisplatin Induces Renal Expression Of P Glycoprotein And Canalicular Multispecific Organic Anion Transporter American Journal Of Physiology Renal Physiology
Biology CMOAT abbreviation meaning defined here What does CMOAT stand for in Biology?CMOAT for l h at room temperature and then with horseradish peroxidaselinked second antibody for l h at room temperature Membranes were devel oped by chemiluminescence following the ECL protocol (Amersham Interna tional Buckinghamshire United Kingdom) Drug Resistance of Antisense Transfectants About IO1cells were plated in 35mm dishes in the absence of drugs,They reported that TR − rats, an animal model of DJS, are defective in anion transporter (cMOAT) and found a single nucleotide deletion mutation at nucleotide 1179 in the gene, resulting in reduced mRNA abundance and absence of the protein
Genomic Structure Of The Canalicular Multispecific Organic Anion Transporter Gene Mrp2 Cmoat And Mutations In The Atp Binding Cassette Region In Dubin Johnson Syndrome The American Journal Of Human Genetics
Irinotecan Mechanisms Of Tumor Resistance And Novel Strategies For Modulating Its Activity Annals Of Oncology
Bedeutung des ABCTransporters MRP2/cMOAT/ABCC2 bei der Cisplatinresistenz humaner Tumorzellen / von Verena Waltraut Materna, geb Schaub Human cMOAT cDNA transfectants (CHO/cMOAT1, 2 and LLC/cMOAT1, 2 cells) expressed human cMOAT of molecular weight of 180–190 kDa, while cells transfected with empty vector alone (CHO/CMV and LLC/CMV cells) and parental cells (CHOK1 and LLCPK1 cells) did not express human cMOATThe most extensively studied member of this family is cMOAT, the canalicular Multispecific Organic Anion Transporter The substrate specificity of this pump was originally defined by an inborn error in rats, lacking this protein These rats are mildly hyperbilirubinemic, because of their inability to secrete bilirubin glucuronides into their bile In addition, they have diminished capacity to secrete a variety of other organic anions Absence of cMOAT
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Ook wel het MRP2 gen) is het gen dat verantwoordelijk is voor een van de transporters in de lever die gal afvoert van de levercel naar de galwegen Een mutatie in dit gen veroorzaakt het DubinJohnson syndroom, een goedaardige vorm van geelzucht, waarbij gal moeilijk getransporteerd kan worden naar deThe human cMOAT gene encodes a membrane protein involved in the ATPdependent transport of hydrophobic compounds To determine whether cMOAT is associated with drug sensitivity, we transfected an expression vector containing cMOAT antisense cDNA into the HepG2 human hepatic cancer cell line We obse The cMOAT expression levels did not correlate with antemortem platinum drug exposure Next, we monitored gammaGCS heavy subunit expression levels in peripheral mononuclear cells of eight
Effect Of Multidrug Resistance Reversing Agents On Transporting Activity Of Human Canalicular Multispecific Organic Anion Transporter Molecular Pharmacology
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Find out what is the full meaning of CMOAT on Abbreviationscom!See what Clarissa Moats (cmoat) has discovered on , the world's biggest collection of ideasAus dem Zentrum für Lebensmittelwissenschaften Institut für Lebensmitteltoxikologie und Chemische Analytik Lebensmitteltoxikologie der Tierärztlichen Hochschule Hannover
Figure 4 From Physicochemical Parameters Responsible For The Affinity Of Methotrexate Analogs For Rat Canalicular Multispecific Organic Anion Transporter Cmoat Mrp2 Semantic Scholar
Delineating The Contribution Of Secretory Transporters In The Efflux Of Etoposide Using Madin Darby Canine Kidney Mdck Cells Overexpressing P Glycoprotein Pgp Multidrug Resistance Associated Protein Mrp1 And Canalicular Multispecific Organic
The complementary DNA (cDNA) encoding rat cmoat has recently been cloned, and the mutation underlying the defect in TRrats has been identified In the present study, we have isolated the human homologue of rat cmoat, human cMOAT, and analyzed the corresponding cDNA from fibroblasts of a DJS patient for mutations Our results show that aHow is the B2B market developing? Recently, Paulusma et al demonstrated that rat cMOAT is a liverspecific homolog of the MRP;
Delineating The Contribution Of Secretory Transporters In The Efflux Of Etoposide Using Madin Darby Canine Kidney Mdck Cells Overexpressing P Glycoprotein Pgp Multidrug Resistance Associated Protein Mrp1 And Canalicular Multispecific Organic
Biochemical And Molecular Aspects Of Genetic Disorders Of Bilirubin Metabolism Sciencedirect
Assignment of the canalicular multispecific organic anion transporter gene (CMOAT) to human chromosome 10q24 and mouse chromosome 19D2 by fluorescent in situ hybridization Published in Cytogenetics and cell genetics, 77(34), 285 287 S Karger AG ISSN Author cMOAT encodes an ATPase within the family of cMOAT/MRP ATPases that functions as an ATP dependent, multispecific anion transporter within the canalicular surface of hepatocytes that has pharmacologic significance We describe here the cloning of a murine cMOAT cDNA isolated from mouse liver The open reading frame of this cDNA incorporates 4627 nucleotides cMOAT encodes an ATPase within the family of cMOAT/MRP ATPases that functions as an ATP dependent, multispecific anion transporter within the canalicu
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About Press Copyright Contact us Creators Advertise Developers Terms Privacy Policy & Safety How works Test new features Press Copyright Contact us CreatorsGet the top CMOAT abbreviation related to BiologyThis antibody reacts with an internal epitope of MRP2, a 1900 kDa transmembrane protein previously known as the canalicular multiorganic anion transporter (cMOAT) MRP2 is a member of the MRP family of multidrug resistance related proteins, and MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines This antibody does not crossreact with the
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PURPOSE The purpose of the present study is to investigate the expression of canalicular multispecific organic anion transporter (cMOAT) by its cDNA transfection in polarized MadinDarby canine kidney cells (MDCK) METHODS MDCK cells were transfected with an expression vector (pCXN2) containing the rat cMOAT cDNA with lipofectamine to obtain the stable transfectant under G418 Cells from a single colony whose cMOATPurpose The purpose of the present study is to investigate the expression of canalicular multispecific organic anion transporter (cMOAT) by its cDNA transfection in polarized MadinDarby canine kidney cells (MDCK) Methods MDCK cells were transfected with an expression vector (pCXN2) containing the rat cMOAT cDNA with lipofectamine to obtain the stable transfectantThe present study was designed to investigate the intestinal absorption and efflux mechanisms of CPT11 using in vitro cell culture models, Caco2 cells, and engineered MadineDarby canine kidney (MDCK) II cells overexpressing Pglycoprotein (Pgp), canalicular multispecific organic anion transporter (cMOAT), and multidrug resistanceassociated protein (MRP1) The intestinal
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CMOAT encodes an ATPase within the family of cMOAT/MRP ATPases that functions as an ATP dependent, multispecific anion transporter within the canalicular surface of hepatocytes that has pharmacologic significance We describe here the cloning of a murine cMOAT cDNA isolated from mouse liver The open reading frame of this cDNA incorporates 4627 nucleotides encoding 1309'Canalicular Multispecific Organic Anion Transporter' is one option get in to view more @ The Web's largest and most authoritative acronyms and abbreviations resourceCMOAT Organism Homo sapiens (Human) Status UnreviewedAnnotation score Protein predicted i Names & Taxonomy i Protein names i Submitted name Canalicular multispecific organic anion transporter Imported Gene names
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Metabolism Of Hepatic Bilirubin Alb Serum Albumin Cbat Canalicular Download Scientific Diagram
What does CMOAT Full From stand for, Meaning, What is Full Form is?CMOAT enhanced the sensitivity of multiple anticancer drugs, including cisplatin, in human hepatic cancer cells13) However, analyses of cMOAT expression in primary cancers and its relevance to
Genomic Structure Of The Canalicular Multispecific Organic Anion Transporter Gene Mrp2 Cmoat And Mutations In The Atp Binding Cassette Region In Dubin Johnson Syndrome The American Journal Of Human Genetics
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Dexamethasone Modulation Of Multidrug Transporters In Normal Tissues Demeule 1999 Febs Letters Wiley Online Library
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Genomic Structure Of The Canalicular Multispecific Organic Anion Transporter Gene Mrp2 Cmoat And Mutations In The Atp Binding Cassette Region In Dubin Johnson Syndrome The American Journal Of Human Genetics
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The Mrp2 Cmoat Transporter And Arsenic Glutathione Complex Formation Are Required For Biliary Excretion Of Arsenic Journal Of Biological Chemistry
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Cisplatin Induces Renal Expression Of P Glycoprotein And Canalicular Multispecific Organic Anion Transporter American Journal Of Physiology Renal Physiology
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Co Administration Of Probenecid An Inhibitor Of A Cmoat Mrp Like Plasma Membrane Atpase Greatly Enhanced The Efficacy Of A New 10 Deazaaminopterin Against Human Solid Tumors In Vivo Clinical Cancer Research
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Molecular Aspects Of Organic Compound Transport Across The Plasma Membrane Of Hepatocytes Kamisako 1999 Journal Of Gastroenterology And Hepatology Wiley Online Library
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Abcc2 Mrp2 Cmoat Can Be Localized In The Nuclear Membrane Of Ovarian Carcinomas And Correlates With Resistance To Cisplatin And Clinical Outcome Clinical Cancer Research
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